Aunt Libby’S Southern Comfort Meatloaf
Prep: 15 minutes
Cook: 1 to 1 1/2 hours
Yields: 4 servings
Get ready to sink your teeth into the juiciest, most tender meatloaf of your life!
Today, we’re diving into the world of Southern comfort food, and trust me, you won’t want to miss this! Aunt Libby’s secret recipe is about to become your new go-to for a satisfying dinner that’ll leave everyone begging for seconds.

First, preheat your oven to 350 degrees F (175 degrees C). Yes, it’s time to get cozy in the kitchen! Butter a 9×5-inch loaf pan, because we’re about to get our meatloaf on!
In a large bowl, mix together 2 pounds of ground beef (don’t even think about using turkey, folks!), 1 chopped onion, 1 cup of ketchup, 1 cup of Italian-seasoned bread crumbs, 2 eggs, 1 ½ teaspoons of salt, and ¼ teaspoon of ground black pepper. Get in there with your hands and mix it up like you mean it!

Press that beef mixture into a loaf shape in the prepared loaf pan. You got this!
Now, let’s talk sauce. In a saucepan, mix together 1 ½ cups of ketchup, ¼ cup of water, 3 tablespoons of white wine vinegar, 3 tablespoons of brown sugar, 2 tablespoons of Dijon mustard, and 2 teaspoons of Worcestershire sauce. Cook and stir over medium heat until the sauce is smooth and warm, about 10 minutes. Yes, it’s worth the wait!

Pour about 1/3 of the sauce over the meatloaf. You’re getting close!
Bake in the preheated oven, basting every 25 minutes with more sauce, until the meatloaf is cooked through, 1 to 1 1/2 hours. An instant-read thermometer inserted into the center should read at least 160 degrees F (70 degrees C).

Let it cool in the pan for 10 minutes before slicing. The hardest part is waiting!
And that’s it! Slice, serve, and enjoy the oohs and aahs from your family and friends. Trust us, this meatloaf is a real showstopper!

Printable Recipe
Ingredients
- 2 pounds ground beef
- 1 chopped onion
- 1 cup ketchup
- 1 cup Italian-seasoned bread crumbs
- 2 eggs
- 1 ½ teaspoons salt
- ¼ teaspoon ground black pepper
- 1 ½ cups ketchup (for sauce)
- ¼ cup water
- 3 tablespoons white wine vinegar
- 3 tablespoons brown sugar
- 2 tablespoons Dijon mustard
- 2 teaspoons Worcestershire sauce
Instructions
- 1. Preheat your oven to 350 degrees F (175 degrees C).
- 2. Butter a 9x5-inch loaf pan.
- 3. In a large bowl, mix together 2 pounds of ground beef, 1 chopped onion, 1 cup of ketchup, 1 cup of Italian-seasoned bread crumbs, 2 eggs, 1 ½ teaspoons of salt, and ¼ teaspoon of ground black pepper.
- 4. Press the beef mixture into a loaf shape in the prepared loaf pan.
- 5. In a saucepan, mix together 1 ½ cups of ketchup, ¼ cup of water, 3 tablespoons of white wine vinegar, 3 tablespoons of brown sugar, 2 tablespoons of Dijon mustard, and 2 teaspoons of Worcestershire sauce. Cook and stir over medium heat until the sauce is smooth and warm, about 10 minutes.
- 6. Pour about 1/3 of the sauce over the meatloaf.
- 7. Bake in the preheated oven, basting every 25 minutes with more sauce, until the meatloaf is cooked through, approximately 1 to 1 1/2 hours.
- 8. An instant-read thermometer inserted into the center should read at least 160 degrees F (70 degrees C).
- 9. Let the meatloaf cool in the pan for 10 minutes before slicing.
- 10. Slice, serve, and enjoy.
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